Sex?Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function

Males and females respond differently to medications due physiologic, metabolic, genetic factors. At times, sex-related differences cannot be mitigated by dose adjustment body mass, are evident from the tissue level single cell. The rising number of clinically approved nanotechnologies calls for assessing how their activity is affected patient's sex. Herein, sex in nanotechnology scoped, with emphasis on molecular considerations. Sex-specific pharmacokinetics nanocarriers influenced nanoparticle's composition, its size, architecture. biodistribution immune response nanoparticles males females, influence have hormones, fertility, toxicity, discussed. Despite importance, effect design implementation nanomedicines underresearched. it aimed raise awareness preclinical clinical evaluation nanotechnologies.